Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo

In vivo endotoxin tolerance

Endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide (LPS) challenge following a first encounter with endotoxin. Endotoxin tolerance protects against a lethal challenge of LPS and prevents infection and ischemia-reperfusion damage. Endotoxin tolerance is paralleled by a dramatic reduction of tumor necrosis factor (TNF) production and some other cytokines in respons...

Tolerance-Related Immunoparalysis Flt3 Ligand Treatment Reverses Endotoxin

Endotoxin-induced activation of the coagulation cascade in humans: effect of acetylsalicylic acid and acetaminophen.

During Gram-negative septic shock, lipopolysaccharide (LPS, endotoxin) induces tissue factor (TF) expression. TF expression is mediated by nuclear factor kappaB and amplified by activated platelets. TF forms a highly procoagulant complex with activated coagulation factor VII (FVIIa). Hence, we hypothesized that aspirin, which inhibits LPS-induced, nuclear factor kappaB-dependent TF expression i...

modern surgical techniques in treatment of patients with cleft lip & cleft palate

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تعیین ارزش غذایی برخی از ضایعات کشاورزی با استفاده از روشهای ,in vitro,in situ in vivo

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